Desert Strike is a shoot 'em up game in which the player pilots an AH-64 Apache helicopter. The game is less frantic than typical shoot 'em ups, with the addition of greater strategic elements. The action takes place on open, multi-directional scrolling levels viewed from an isometric perspective. The player views the action from outside the helicopter, rather than from within the cockpit.

Levels consist of several missions, which are based around the destruction of enemy weapons and installations, as well as rescuing hostages or prisoners of war, or capturing enemy personnel. The Apache is armed with a machine gun, more powerful Hydra rockets and yet more deadly Hellfire missiles. The more powerful the weapon, the fewer can be carried: the player must choose an appropriate weapon for each situation. Enemy weapons range from soldiers with small arms, to anti-aircraft missiles to tanks and armoured cars.

The player's craft has a limited amount of armour, which is depleted as the helicopter is hit by enemy fire. Should the armour reach zero, the craft will be destroyed, costing the player a life. The player must outmanoeuvre enemies to avoid damage, but can replenish armour by means of power-ups or by airlifting rescued friendlies or captives to a landing zone. The helicopter has a finite amount of fuel which is steadily depleted over time. Should the fuel run out the Apache will crash, again costing the player a life. The craft can refuel by collecting fuel barrels: the player must therefore plan mission routes carefully in order to maximise efficiency. The helicopter also carries limited ammunition, which must be replenished by means of ammo crates.